A good article on the subject is available HERE
OWL and OWLiver Test
OWL propose a serum based NASH diagnosis using metabolomics.
In 2006, an article published by
Li, Z., Agellon, L.B., Allen, T.M., Umeda, M., Jewell, L., Mason, A. and Vance, D.E. (2006) The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metab. 3, 321–331 CrossRef PubMed
described a key role for membrane integrity in the advance of NAFLD and the NAFLD PC/PE ratios dependence in the cells membrane’s lipids
In a more récent article published in BIOCHIMICAL SOCIETY TRANSACTION by AinaraCano and CristinaAlonso :
"Deciphering non-alcoholic fatty liver disease through metabolomics"
Ainara Cano*1 and Cristina Alonso*
*OWL, Parque Cientı ́fico y Tecnolo ́ gico de Bizkaia, Spain
the authors explain the path using metabolomics to find out the metabolic fluxes that underlie membrane integrity in NAFLD.
OWL already propose the biomarker diagnosis for NASH the OWLiver Test and will present it in the 2016 EASL meeting in Barcelona.
The previous vidéo are not endorsed by NASHBIOTECHS but cited as references provided by OWL on their website to present OWLiver Test technology
During the EASL meeting in Barcelona in april 2016, OWL made three presentations on their tests available here !
GENFIT and its biomarkers technology
September the 15th 2015 GENFIT advertise that their method of diagnosis will be available simultaneously with the placing on the market ELAFIBRANOR.
At this time, we do not have a lot of technical informations on the GENFIT Biomarkers program but the poster they presented on the subject is full of informations
VLVBio
M30 Apoptosense® ELISA - A reliable non-invasive tool for the detection and screening of NASH
The M30 Apoptosense® ELISA measures the concentration of K18 fragments and is a specific and reliable tool for the detection and screening of NASH. Two recent meta-analyses demonstrated that levels of K18 fragments predict the presence of NASHwith a pooled AUROC of 0.82, 78 % sensitivity and 86 % specificity and AUROC of 0.8445, 83 % sensitivity and 71 % specificity, respectively.